Reaction: GGCX gamma-carboxylates F7(21-466) (pro-factor VII)
- in pathway: Gamma-carboxylation of protein precursors
GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates ten glutamate residues on F7(21-466) (pro-factor VII). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
MK4 epoxide [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
MK4 [endoplasmic reticulum lumen]
CO2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-159761
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Reaction input - small molecules:
dioxygen
menaquinone-4
carbon dioxide
Reaction output - small molecules:
water
2,3-epoxymenatetrenone
Reactome.org link: R-HSA-159761