Reaction: NEU2 cleaves GM3 to form LacCer (cytosol)
- in pathway: Glycosphingolipid catabolism
Sialidase-2 (NEU2) hydrolyses Neu5Ac from GM3 in the cytosol (Monti et al. 1999).
Reaction - small molecule participants:
Neu5Ac [cytosol]
LacCer [cytosol]
GM3 [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-1605723
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Reaction input - small molecules:
alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine(1-)
water
Reaction output - small molecules:
N-acetylneuraminate
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-acylsphingoid
Reactome.org link: R-HSA-1605723