Reaction: NEU3 cleaves GM3 to form LacCer (plasma membrane)
- in pathway: Glycosphingolipid catabolism
Sialidase-3 (NEU3) cleaves Neu5Ac from GM3 in the plasma membrane. NEU3 is thought to play a role in modulating the ganglioside content of the lipid bilayer (Monti et al. 2000).
Reaction - small molecule participants:
Neu5Ac [cytosol]
LacCer [plasma membrane]
H2O [cytosol]
GM3 [plasma membrane]
Reactome.org reaction link: R-HSA-1605768
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Reaction input - small molecules:
water
alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine(1-)
Reaction output - small molecules:
N-acetylneuraminate
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-acylsphingoid
Reactome.org link: R-HSA-1605768