Reaction: SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)
- in pathway: Glycosphingolipid catabolism
The mammalian brain-specific, Mg2+-dependent, neutral sphingomyelin phosphodiesterases 2 (Tomiuk et al. 1998, Hofmann et al. 2000) and 3 (Marchesini et al. 2003) (SMPD2 and 3) hydrolyse sphingomyelin (SPHM) to ceramide (CERA) at the plasma membrane.
Reaction - small molecule participants:
H+ [cytosol]
CERA [plasma membrane]
ChoP [plasma membrane]
H2O [cytosol]
SPHM [plasma membrane]
Reactome.org reaction link: R-HSA-1606273
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Reaction input - small molecules:
water
sphingomyelin d18:1
Reaction output - small molecules:
hydron
N-acylsphingoid
choline phosphate(1-)
Reactome.org link: R-HSA-1606273