Reaction: Excess homocysteine yields homolanthionine and H2S
- in pathway: Degradation of cysteine and homocysteine
Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)
Reaction - small molecule participants:
H2S [cytosol]
HLAN [cytosol]
HCYS [cytosol]
Reactome.org reaction link: R-HSA-1614567
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Reaction input - small molecules:
homocysteine zwitterion
Reaction output - small molecules:
hydrosulfide
L-homolanthionine
Reactome.org link: R-HSA-1614567