Reaction: PXLP-K212-CTH cleaves L-Cystathionine
- in pathway: Cysteine formation from homocysteine
Cystathionine is cleaved to cysteine, oxobutanoate, and ammonia by the alpha,gamma-elimination activity of cystathionine gamma-lyase (CTH). CTH utilises pyridoxal 5'-phosphate (PXLP) as cofactor (Chiku et al. 2009, Steegborn et al. 1999).
Reaction - small molecule participants:
L-Cys [cytosol]
NH3 [cytosol]
2OBUTA [cytosol]
L-Cystathionine [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-1614583
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Reaction input - small molecules:
L-cystathionine
water
Reaction output - small molecules:
L-cysteine zwitterion
ammonia
2-oxobutanoic acid
Reactome.org link: R-HSA-1614583