Reaction: Excess cysteine yields lanthionine and H2S
- in pathway: Degradation of cysteine and homocysteine
Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)
Reaction - small molecule participants:
L-Lanthionine [cytosol]
H2S [cytosol]
L-Cys [cytosol]
Reactome.org reaction link: R-HSA-1614591
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Reaction input - small molecules:
L-cysteine zwitterion
Reaction output - small molecules:
L-lanthionine
hydrosulfide
Reactome.org link: R-HSA-1614591