Reaction: Cysteine is degraded to serine and H2S
- in pathway: Degradation of cysteine and homocysteine
alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).
Reaction - small molecule participants:
H2S [cytosol]
L-Ser [cytosol]
H2O [cytosol]
L-Cys [cytosol]
Reactome.org reaction link: R-HSA-1614614
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Reaction input - small molecules:
water
L-cysteine zwitterion
Reaction output - small molecules:
hydrosulfide
L-serine zwitterion
Reactome.org link: R-HSA-1614614