Reaction: Homocysteine is degraded to oxobutanoate and H2S
- in pathway: Degradation of cysteine and homocysteine
Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)
Reaction - small molecule participants:
H2S [cytosol]
NH3 [cytosol]
2OBUTA [cytosol]
H2O [cytosol]
HCYS [cytosol]
Reactome.org reaction link: R-HSA-1614631
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Reaction input - small molecules:
water
homocysteine zwitterion
Reaction output - small molecules:
hydrosulfide
ammonia
2-oxobutanoic acid
Reactome.org link: R-HSA-1614631