Reaction: BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY
- in pathway: Choline catabolism
Remethylation of homocysteine (HCYS) to methionine (L-Met) can also proceed by using betaine (BET) as a methyl donor, which is oxidised to dimethylglycine (DMGLY). This reaction is also part of choline catabolism, thereby providing a link to folate-dependent, one-carbon metabolism (Li et al. 2008).
Reaction - small molecule participants:
L-Met [cytosol]
DMGLY [cytosol]
BET [cytosol]
HCYS [cytosol]
L-Met [cytosol]
DMGLY [cytosol]
BET [cytosol]
HCYS [cytosol]
Reactome.org reaction link: R-HSA-1614654
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Reaction input - small molecules:
glycine betaine
homocysteine zwitterion
glycine betaine
homocysteine zwitterion
Reaction output - small molecules:
L-methionine zwitterion
N,N-dimethylglycine zwitterion
L-methionine zwitterion
N,N-dimethylglycine zwitterion
Reactome.org link: R-HSA-1614654