Reaction: SQR oxidizes sulfide to bound persulfide
- in pathway: Sulfide oxidation to sulfate
When SQR is in the oxidized state, it can bind hydrogen sulfide as persulfide to one of its own cysteine residue, the electrons being transferred to ubiquinone. After that the additional sulfur is dioxygenated by another enzyme (ETHE1). The activity of human SQR was deduced from the orthologue in Arenicola marina (Theissen et al. 2003, Hildebrandt & Grieshaber 2008).
Reaction - small molecule participants:
QH2 [mitochondrial inner membrane]
CoQ [mitochondrial inner membrane]
H+ [mitochondrial inner membrane]
H2S [cytosol]
Reactome.org reaction link: R-HSA-1614665
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Reaction input - small molecules:
coenzyme Q10
hydron
hydrosulfide
Reaction output - small molecules:
ubiquinol
Reactome.org link: R-HSA-1614665