Reaction: glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH
- in pathway: Synthesis of glycosylphosphatidylinositol (GPI)
In the fourth step of GPI synthesis, an acyl group (typically palmitate) is transferred from acyl CoA to glucosaminyl-PI. Mutagenesis and cloning studies suggest that a single protein, PIG-W, catalyzes this reaction (Murakami et al. 2003).
Reaction - small molecule participants:
glucosaminyl-acyl-PI [integral component of cytoplasmic side of endoplasmic reticulum membrane]
CoA-SH [cytosol]
FACoA [cytosol]
glucosaminyl-PI [integral component of cytoplasmic side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-162683
======
Reaction input - small molecules:
fatty acyl-CoA(4-)
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol zwitterion
Reaction output - small molecules:
acylglucosaminylphosphatidylinositol
coenzyme A(4-)
Reactome.org link: R-HSA-162683