Reaction: dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose
- in pathway: Synthesis of dolichyl-phosphate mannose
Cytosolic GDP-mannose reacts with dolichyl phosphate in the endoplasmic reticulum membrane to form dolichyl phosphate D-mannose (DOLPman). The reaction is catalysed by dolichyl-phosphate mannosyltransferase, a heterotrimeric protein embedded in the endoplasmic reticulum membrane. The first subunit of the heterotrimer (DPM1) appears to be the actual catalyst, and the other two subunits appear to stabilise it (Maeda et al. 2000).
Reaction - small molecule participants:
GDP [cytosol]
DOLP-Man [integral component of cytoplasmic side of endoplasmic reticulum membrane]
GDP-Man [cytosol]
DOLP [integral component of cytoplasmic side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-162721
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Reaction input - small molecules:
GDP-alpha-D-mannose(2-)
dolichyl phosphate(2-)
Reaction output - small molecules:
GDP(3-)
dolichyl D-mannosyl phosphate(1-)
Reactome.org link: R-HSA-162721