Reaction: uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid
- in pathway: Attachment of GPI anchor to uPAR
The fatty acid group added to inositol in the fourth step of GPI biosynthsis is removed from GPI-conjugated uPAR. This hydrolysis event occurs in the endoplasmic reticulum and appears to be associated with efficient transport of the conjugated protein from the endoplasmic reticulum to the Golgi apparatus (Tanaka et al. 2004).
Reaction - small molecule participants:
LCFA(-) [endoplasmic reticulum membrane]
H2O [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-162729
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Reaction input - small molecules:
water
Reaction output - small molecules:
long-chain fatty acid anion
Reactome.org link: R-HSA-162729