Reaction: mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate
- in pathway: Synthesis of glycosylphosphatidylinositol (GPI)
In the eighth reaction of GPI synthesis, a third mannose residue is added, catalyzed by PIG-B (Takahashi et al. 1996).
Reaction - small molecule participants:
mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI [integral component of lumenal side of endoplasmic reticulum membrane]
dolichyl phosphate [endoplasmic reticulum membrane]
DOLP-Man [integral component of lumenal side of endoplasmic reticulum membrane]
mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI [integral component of lumenal side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-162821
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Reaction input - small molecules:
dolichyl D-mannosyl phosphate(1-)
6-O-{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol
Reaction output - small molecules:
6-O-{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol
dolichyl phosphate(2-)
Reactome.org link: R-HSA-162821