Reaction: glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate
- in pathway: Synthesis of glycosylphosphatidylinositol (GPI)
In the fifth step of GPI synthesis, a mannose residue is added to glucosaminyl-acyl-PI. The reaction takes place at the lumenal surface of the endoplasmic reticulum membrane. It is catalyzed by a complex of at least two components, PIG-M and PIG-X (Maeda et al. 2001; Ashida et al. 2005).
Reaction - small molecule participants:
mannose (a1-4) glucosaminyl-acyl-PI [integral component of lumenal side of endoplasmic reticulum membrane]
dolichyl phosphate [endoplasmic reticulum membrane]
DOLP-Man [integral component of lumenal side of endoplasmic reticulum membrane]
glucosaminyl-acyl-PI [integral component of lumenal side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-162830
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Reaction input - small molecules:
dolichyl D-mannosyl phosphate(1-)
acylglucosaminylphosphatidylinositol
Reaction output - small molecules:
6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol
dolichyl phosphate(2-)
Reactome.org link: R-HSA-162830