Reaction: Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane
- in pathway: Synthesis of glycosylphosphatidylinositol (GPI)
GPI moieties are synthesized anchored to dolichol phosphate in the membrane of the endoplasmic reticulum. The first two steps of the synthetic pathway, leading to the production of glucosaminyl-PI, occur on the cytosolic face of the membrane, while addition of an acyl group (step 4) and all subsequent steps occur on the lumenal face (Murakami et al. 2003). No mutant cell lines defective in the reorientation step have been identified, and the mechanism by which it occurs is unknown.
Reaction - small molecule participants:
glucosaminyl-acyl-PI [integral component of lumenal side of endoplasmic reticulum membrane]
glucosaminyl-acyl-PI [integral component of cytoplasmic side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-162840
======
Reaction input - small molecules:
acylglucosaminylphosphatidylinositol
Reaction output - small molecules:
acylglucosaminylphosphatidylinositol
Reactome.org link: R-HSA-162840