Reaction: N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate
- in pathway: Synthesis of glycosylphosphatidylinositol (GPI)
In the second step of GPI synthesis, N-acetylglucosaminyl-PI is hydrolyzed to yield glucosaminyl-PI and acetate. The phosphatidylinositol (PI) derivatives involved in this reaction are located in the endoplasmic reticulum membrane, as is the PIG-L enzyme that catalyzes it (Sharma et al. 1999; Pottekat and Menon 2004).
Reaction - small molecule participants:
glucosaminyl-PI [integral component of cytoplasmic side of endoplasmic reticulum membrane]
CH3COO- [cytosol]
N-acetylglucosaminyl-PI [integral component of cytoplasmic side of endoplasmic reticulum membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-162857
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Reaction input - small molecules:
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
water
Reaction output - small molecules:
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol zwitterion
acetic acid
Reactome.org link: R-HSA-162857