Reaction: Down Regulation of Emi1 through Phosphorylation of Emi1
- in pathway: Mitotic Metaphase/Anaphase Transition
During the early stages of mitosis, Cdc2 and PLK1 cooperate to phosphorylate Emi1 and this modification induces Emi1 degradation through a Skp1-Cullin1 F-box protein (SCF) ubiquitin ligase-mediated proteolysis. Degradation of Emi1 permits activation of anaphase promoting complex and thereby the onset of anaphase.
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-163010
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-163010