Reaction: cholesterol ester + H2O -> cholesterol + fatty acid
- in pathway: Triglyceride catabolism
Activated rat HSL hydrolyzes cholesterol ester to yield cholesterol + fatty acid (Fredrikson et al. 1981). The human reaction has not been studied in detail, and is inferred from the well-characterized rat one.
Reaction - small molecule participants:
LCFA(-) [cytosol]
CHOL [lipid droplet]
H2O [cytosol]
CHEST [lipid droplet]
Reactome.org reaction link: R-HSA-163432
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Reaction input - small molecules:
water
cholesteryl ester
Reaction output - small molecules:
long-chain fatty acid anion
cholesterol
Reactome.org link: R-HSA-163432