Reaction: 2-acylglycerol + H2O -> glycerol + fatty acid
- in pathway: Triglyceride catabolism
Rat monoacylglycerol lipase (MGLL) catalyzes the hydrolysis of 2-acylglycerol to yield glycerol + fatty acid (Tornqvist and Belfrage 1976; Fredrikson et al. 1986). Localization of the enzyme to lipid particles is plausible, given its low solubility and its involvement in acylglycerol metabolism, but this localization has not been directly experimentally verified. The human reaction is inferred from the well-studied rat one.
Reaction - small molecule participants:
LCFA(-) [cytosol]
Glycerol [cytosol]
2-acylglycerol [lipid droplet]
H2O [cytosol]
Reactome.org reaction link: R-HSA-163595
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Reaction input - small molecules:
2-monoglyceride
water
Reaction output - small molecules:
long-chain fatty acid anion
glycerol
Reactome.org link: R-HSA-163595