Reaction: Phosphorylation of ChREBP at Serine 556 by AMPK
- in pathway: AMPK inhibits chREBP transcriptional activation activity
In the nucleus, activated AMPK phosphorylates serine residue 556 of ChREBP (Carbohydrate Response Element Binding Protein). Phosphorylated ChREBP does not bind to ChRE chromosomal DNA sequence elements and thus loses its ability to promote transcription of genes involved in glycolysis and lipogenesis.
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-163691
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-163691