Reaction: D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
- in pathway: Pentose phosphate pathway
Dimeric cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-erythrose 4-phosphate and D-fructose 6-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. Protein expressed from the cloned gene has been characterized biochemically and crystallographically (Banki et al. 1994; Thorell et al. 2000) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).
Reaction - small molecule participants:
GA3P [cytosol]
SH7P [cytosol]
Fru(6)P [cytosol]
E4P [cytosol]
GA3P [cytosol]
SH7P [cytosol]
Fru(6)P [cytosol]
E4P [cytosol]
Reactome.org reaction link: R-HSA-163764
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Reaction input - small molecules:
beta-D-fructofuranose 6-phosphate(2-)
D-erythrose 4-phosphate(2-)
beta-D-fructofuranose 6-phosphate(2-)
D-erythrose 4-phosphate(2-)
Reaction output - small molecules:
D-glyceraldehyde 3-phosphate(2-)
sedoheptulose 7-phosphate
D-glyceraldehyde 3-phosphate(2-)
sedoheptulose 7-phosphate
Reactome.org link: R-HSA-163764