Reaction: GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)
- in pathway: Gamma-carboxylation of protein precursors
GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eleven glutamate residues on GAS6(31-691) (pro-GAS6). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process. The details of the gamma-carboxylation of GAS6 have not been determined directly, but are inferred from those worked out for protein S (Manfioletti et al. 1993).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
MK4 epoxide [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
MK4 [endoplasmic reticulum lumen]
CO2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-163810
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Reaction input - small molecules:
dioxygen
menaquinone-4
carbon dioxide
Reaction output - small molecules:
water
2,3-epoxymenatetrenone
Reactome.org link: R-HSA-163810