Reaction: ENPP7 hydrolyzes sphingomyelin
- in pathway: Glycosphingolipid catabolism
Membrane-bound ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) mediates the hydrolysis of sphingomyelin to ceramide and choline phosphate (Duan et al. 2003, Wu et al. 2005).
Reaction - small molecule participants:
H+ [cytosol]
CERA [plasma membrane]
ChoP [plasma membrane]
H2O [cytosol]
SPHM [plasma membrane]
Reactome.org reaction link: R-HSA-1640164
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Reaction input - small molecules:
water
sphingomyelin d18:1
Reaction output - small molecules:
hydron
N-acylsphingoid
choline phosphate(1-)
Reactome.org link: R-HSA-1640164