Reaction: Phosphorylation of TSC2 by PKB
- in pathway: Inhibition of TSC complex formation by PKB
PKB phosphorylates TSC2 decreasing its activity and disrupting TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) which induces ubiquination of the free TSC2 (Inoki et al. 2002).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-165162
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-165162