Reaction: Phosphorylation of Ribosomal protein S6 by activated S6K1
- in pathway: mTORC1-mediated signalling
Once phosphorylated, S6K1-P phosphorylates and activates ribosomal protein S6 (rpS6), which in turn selectively increases the translation of 5'-TOP mRNAs. These mRNAs encode exclusively for components of the translation machinery (PMID 15809305).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-165726
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-165726