Reaction: Association of LBP with LPS
- in pathway: Toll Like Receptor 4 (TLR4) Cascade
Lipopolysaccharide-binding protein (LBP) is a ~60-kDa serum glycoprotein which transfers LPS to both membrane-bound and soluble CD14. The LPS binding site of LBP consists of basic residues that bind the phosphorylated head of the bacterial lipid A.
LBP is an acute-phase opsonin that binds gram-negative bacteria and bacterial fragments and promote the interaction of coated bacteria with phagocytes.
Reaction - small molecule participants:
LPS [extracellular region]
Reactome.org reaction link: R-HSA-166015
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Reaction input - small molecules:
lipopolysaccharide
Reaction output - small molecules:
Reactome.org link: R-HSA-166015