Reaction: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
- in pathway: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-166119
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-166119