Reaction: Formation of DSIF:NELF:HIV-1 early elongation complex
- in pathway: Formation of the HIV-1 Early Elongation Complex
This HIV-1 event was inferred from the corresponding human RNA Pol II transcription event.
NELF complex is a ~ 300 kDa multiprotein complex composed of 5 peptides (A - E): ~66,61,59,58 and 46 kDa (Yamaguchi et al 1999). All these peptides are required for NELF-mediated inhibition of Pol II elongation. NELF complex has been reported to bind to the pre-formed DSIF:RNA Pol II complex that may act as a scaffold for its binding. NELF-A is suspected to be involved in Wolf-Hirschhorn syndrome. Binding of DSIF:NELF to RNA Pol II CTD results in abortive termination of early elongation steps by the growing transcripts.
Reaction - small molecule participants:
NTP [nucleoplasm]
NTP [nucleoplasm]
Reactome.org reaction link: R-HSA-167085
======
Reaction input - small molecules:
nucleoside 5'-triphoshate(4-)
Reaction output - small molecules:
nucleoside 5'-triphoshate(4-)
Reactome.org link: R-HSA-167085