Reaction: Addition of nucleotides between position +11 and +30 on HIV-1 transcript
- in pathway: RNA Polymerase II HIV Promoter Escape
RNA polymerase II transcription complexes are susceptible to transcriptional stalling and arrest, when extending nascent transcripts to 30-nt. This susceptibility depends on presence on down-stream DNA, the particular DNA-sequence of the template and presence of transcription factors. Transcription factor TFIIH remains associated to the RNA pol II elongation complex until position +30. At this stage transcription elongation factor TFIIS can rescue stalled transcription elongation complexes. The transcription bubble varies between 13- and 22-nt in size.
Reaction - small molecule participants:
PPi [nucleoplasm]
NTP [nucleoplasm]
Reactome.org reaction link: R-HSA-167115
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Reaction input - small molecules:
nucleoside 5'-triphoshate(4-)
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-167115