Reaction: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
- in pathway: Synthesis of PIPs at the ER membrane
At the endoplasmic reticulum (ER) membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Wong et al. 1997, Gehrmann et al. 1999) or phosphatidylinositol 4-kinase type 2-beta (PI4K2B) (Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).
Reaction - small molecule participants:
ADP [cytosol]
PI4P [endoplasmic reticulum membrane]
ATP [cytosol]
PI [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1675813
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol(1-)
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reactome.org link: R-HSA-1675813