Reaction: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
- in pathway: Synthesis of PIPs at the plasma membrane
At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P).
Reaction - small molecule participants:
PI3P [plasma membrane]
Pi [cytosol]
H2O [cytosol]
PI(3,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-1675836
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
hydrogenphosphate
Reactome.org link: R-HSA-1675836