Reaction: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
- in pathway: Synthesis of PIPs at the late endosome membrane
At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The PIKFYVE kinase component phosphorylates phosphatidylinositol (PI) to phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 1999, Sbrissa et al. 2002). The PAS complex is present in the cytosol and is recruited to the membrane.
Reaction - small molecule participants:
PI5P [late endosome membrane]
ADP [cytosol]
ATP [cytosol]
PI [late endosome membrane]
Reactome.org reaction link: R-HSA-1675866
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol(1-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
ADP(3-)
Reactome.org link: R-HSA-1675866