Reaction: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
- in pathway: Synthesis of PIPs at the Golgi membrane
At the Golgi membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Domin et al. 2000, Arcaro et al. 2000) and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma (PIK3C2G) (Ono et al. 1998, Rozycka et al. 1998, Misawa et al. 1998) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). PIK3C2G phosphorylates phosphatidylinositol (PI) and PI4P but not phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).
Reaction - small molecule participants:
PI(3,4)P2 [Golgi membrane]
ADP [cytosol]
ATP [cytosol]
PI4P [Golgi membrane]
Reactome.org reaction link: R-HSA-1675928
======
Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ADP(3-)
Reactome.org link: R-HSA-1675928