Reaction: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
- in pathway: Synthesis of PIPs at the Golgi membrane
At the Golgi membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 is bound to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). This PIK3C3:PIK2R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).
The following lists the above proteins with their corresponding literature references: PIK3C3:PIK2R4 (Panaretou et al. 1997, Volinia et al. 1995) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
The following lists the above proteins with their corresponding literature references: PIK3C3:PIK2R4 (Panaretou et al. 1997, Volinia et al. 1995) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Reaction - small molecule participants:
ADP [cytosol]
PI3P [Golgi membrane]
ATP [cytosol]
PI [Golgi membrane]
Reactome.org reaction link: R-HSA-1675961
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol(1-)
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
Reactome.org link: R-HSA-1675961