Reaction: PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
- in pathway: Synthesis of PIPs at the early endosome membrane
At the early endosome membrane, phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002) phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).
Reaction - small molecule participants:
PI4P [early endosome membrane]
ADP [cytosol]
PI [early endosome membrane]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1675974
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol(1-)
ATP(4-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP(3-)
Reactome.org link: R-HSA-1675974