Reaction: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
- in pathway: Synthesis of PIPs at the plasma membrane
At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka Synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007, Johenning et al. 2004) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 4-phosphate (PI4P) phosphatidylinositol (PI). The SAC1 domains of SYNJ1 and SYNJ2 demonstrate 4-phosphatase activity.
Reaction - small molecule participants:
Pi [cytosol]
PI [plasma membrane]
H2O [cytosol]
PI4P [plasma membrane]
Reactome.org reaction link: R-HSA-1675988
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol(1-)
Reactome.org link: R-HSA-1675988