Reaction: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
- in pathway: Synthesis of PIPs at the Golgi membrane
At the Golgi membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).
Reaction - small molecule participants:
Pi [cytosol]
PI3P [Golgi membrane]
H2O [cytosol]
PI(3,5)P2 [Golgi membrane]
Reactome.org reaction link: R-HSA-1676005
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
Reactome.org link: R-HSA-1676005