Reaction: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane
- in pathway: Synthesis of PIPs at the early endosome membrane
At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2) and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P).
The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008), MTMR2 (Cao et al. 2008), and MTMR4 (Lorenzo et al. 2006).
The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008), MTMR2 (Cao et al. 2008), and MTMR4 (Lorenzo et al. 2006).
Reaction - small molecule participants:
Pi [cytosol]
PI5P [early endosome membrane]
H2O [cytosol]
PI(3,5)P2 [early endosome membrane]
Reactome.org reaction link: R-HSA-1676105
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
Reactome.org link: R-HSA-1676105