Reaction: PI4P is dephosphorylated to PI by SACM1L at the ER membrane
- in pathway: Synthesis of PIPs at the ER membrane
At the endoplasmic reticulum (ER) membrane, transmembrane protein phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).
Reaction - small molecule participants:
Pi [cytosol]
PI [endoplasmic reticulum membrane]
H2O [cytosol]
PI4P [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-1676124
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol(1-)
Reactome.org link: R-HSA-1676124