Reaction: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
- in pathway: Synthesis of PIPs at the Golgi membrane
At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).
Reaction - small molecule participants:
Pi [cytosol]
PI [Golgi membrane]
PI4P [Golgi membrane]
Reactome.org reaction link: R-HSA-1676133
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol(1-)
Reactome.org link: R-HSA-1676133