Reaction: PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
- in pathway: Synthesis of PIPs at the plasma membrane
At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A) and beta (PIP5K1B) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Tolias et al. 1998).
Reaction - small molecule participants:
PI(3,5)P2 [plasma membrane]
ADP [cytosol]
PI3P [plasma membrane]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1676134
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
ATP(4-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
ADP(3-)
Reactome.org link: R-HSA-1676134