Reaction: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
- in pathway: Synthesis of PIPs at the plasma membrane
At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010), along with phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).
The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002).
The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002).
Reaction - small molecule participants:
ADP [cytosol]
PI(3,4)P2 [plasma membrane]
PI3P [plasma membrane]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1676145
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reactome.org link: R-HSA-1676145