Reaction: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
- in pathway: Synthesis of PIPs at the early endosome membrane
At the early endosome membrane, type I (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4B) (Norris et al. 1997) colocalise with early and recycling endosomes through their C2 domains which bind to the phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) present in these membranes. It is here that phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is dephosphorylated by INPP4A/B to phosphatidylinositol 3-phosphate (PI3P).
Reaction - small molecule participants:
Pi [cytosol]
PI3P [early endosome membrane]
H2O [cytosol]
PI(3,4)P2 [early endosome membrane]
Reactome.org reaction link: R-HSA-1676162
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
Reactome.org link: R-HSA-1676162