Reaction: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane
- in pathway: Synthesis of PIPs at the plasma membrane
At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Tronchere et al. 2004), 3 (MTMR3) (Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).
Reaction - small molecule participants:
Pi [cytosol]
PI5P [plasma membrane]
H2O [cytosol]
PI(3,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-1676203
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
Reactome.org link: R-HSA-1676203