Reaction: PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
- in pathway: Synthesis of PIPs at the Golgi membrane
At the Golgi membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (TPTE2) aka TPIP dephosphorylates phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 4-phosphate (PI4P) (Tapparel et al. 2000, Walker et al. 2001). The transmembrane phosphatase TPTE2 gamma isoform colocalises in the Golgi and the endoplasmic reticulum (Tapparel et al. 2000).
Reaction - small molecule participants:
Pi [cytosol]
PI4P [Golgi membrane]
PI(3,4)P2 [Golgi membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-1676204
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
water
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reactome.org link: R-HSA-1676204