Reaction: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
- in pathway: Synthesis of PIPs at the early endosome membrane
At the early endosome membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Kraq et al. 2010, Arcaro et al. 2000) phosphorylates phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).
Reaction - small molecule participants:
ADP [cytosol]
PI(3,4)P2 [early endosome membrane]
PI4P [early endosome membrane]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1676206
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4-phosphate
ATP(4-)
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reactome.org link: R-HSA-1676206