Reaction: GUSB tetramer hydrolyses CS/HS precursor
- in pathway: HS-GAG degradation
The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from heparan or the linker chain (Oshima et al. 1987). L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).
Reaction - small molecule participants:
GlcA [lysosomal lumen]
linker chain(2) [lysosomal lumen]
H2O [lysosomal lumen]
CS/HS precursor [lysosomal lumen]
Reactome.org reaction link: R-HSA-1678854
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Reaction input - small molecules:
water
beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
Reaction output - small molecules:
D-glucuronic acid
beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
Reactome.org link: R-HSA-1678854