Reaction: iE-DAP elicits a NOD1 response
- in pathway: NOD1/2 Signaling Pathway
Early studies suggested that NOD1 and NOD2 responded to lipopolysaccharides (LPS), but this was later shown to be due to contamination of LPS with bacterial peptidoglycans (PGNs), the true elicitor for NODs. It is generally believed that PGNs bind NOD1 though this remains to be formally demonstrated. NOD1 senses PGN moieties with a minimal dipeptide structure of D-gamma-glutamyl-meso-diaminopimelic acid (iE-DAP), which is unique to PGN structures from all Gram-negative bacteria and certain Gram-positive bacteria, including the genus Listeria and Bacillus. Attachment of acyl residues enhances NOD1 stimulation several hundred fold, possibly by facilitating PGN entry into the cell (Hasegawa et al. 2007).
Reaction - small molecule participants:
iE-DAP [cytosol]
Reactome.org reaction link: R-HSA-168400
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Reaction input - small molecules:
gamma-D-glutamyl-meso-diaminopimelic acid
Reaction output - small molecules:
Reactome.org link: R-HSA-168400